CXC chemokine receptor type 4



CXC chemokine receptor type 4 (CXCR4) is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). The CXRC4 is used by HIV to infect CD4+ T cells. The images at the left and at the right correspond to one representative CXCR4 (3oe0).

3D Structures of CXCR4
3odu – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161+antagonist – human

3oe0, 3oe6, 3oe8, 3oe9 – hCXCR4 residues 2-229 (mutant)/lysozyme residues 1002-1161/hCXCR4 residues 231-319+antagonist

2k03, 2k04, 2k05 - hCXCR4 N-terminal (mutant)+hSDF-1 (mutant)